期刊
NEUROBIOLOGY OF DISEASE
卷 72, 期 -, 页码 37-47出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nbd.2014.05.033
关键词
Alzheimer's disease; Amyloid-beta; Niemann-Pick type C disease; NPC1; Tau; Cholesterol; Lipids
资金
- Swedish Research Council Formas
- Knut and Alice Wallenberg Foundation
- Wolfson Foundation
- Ministry of Science, Education and Sports of the Republic of Croatia
- Unity through Knowledge Fund
- Swedish State Support for Clinical Research
Alzheimer's disease (AD) and Niemann-Pick type C (NPC) disease are progressive neurodegenerative diseases with very different epidemiology and etiology. AD is a common cause of dementia with a complex polyfactorial etiology, including both genetic and environmental risk factors, while NPC is a very rare autosomal recessive disease. However, the diseases share some disease-related molecular pathways, including abnormal cholesterol metabolism, and involvement of amyloid-beta (A beta) and tau pathology. Here we review recent studies on these pathological traits, focusing on studies of A beta and tau pathology in NPC, and the importance of the NPC1 gene in AD. Further studies of similarities and differences between AD and NPC may be useful to increase the understanding of both these devastating neurological diseases. (C) 2014 Elsevier Inc. All rights reserved.
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