期刊
NEUROBIOLOGY OF DISEASE
卷 68, 期 -, 页码 200-214出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nbd.2014.03.008
关键词
Pain; Women; Puberty; Hypothalamus; Cortical spreading depression; Headache; Gonadotrophins; Estrogen; Progesterone; Trigeminal; Allostatic load; Menstrual cycle; Sleep
资金
- NIH from NINDS [K24 NS064050, R01NS056195, R01NS073997]
- NCCAM [R21AT007530]
- [R37 NS079678]
- [R01NS069847]
The brain responds differently to environmental and internal signals that relate to the stage of development of neural systems. While genetic and epigenetic factors contribute to a premorbid state, hormonal fluctuations in women may alter the set point of migraine. The cyclic surges of gonadal hormones may directly alter neuronal, glial and astrocyte function throughout the brain. Estrogen is mainly excitatory and progesterone inhibitory on brain neuronal systems. These changes contribute to the allostatic load of the migraine condition that most notably starts at puberty in girls. (C) 2014 Elsevier Inc. All rights reserved.
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