期刊
NEUROBIOLOGY OF DISEASE
卷 65, 期 -, 页码 203-210出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nbd.2014.01.018
关键词
Multiple sclerosis; Black holes; Microglia; Neurodegeneration; PK11195-PET
资金
- European Federation of Neurological Societies (EFNS)
- Fondazione Italiana Sclerosi Multipla (FISM) [2010/B/7]
- Multiple Sclerosis Trials Collaboration (MSTC)
- NIHR Biomedical Research Centre
- Multiple Sclerosis Society of Great Britain and Northern Ireland [910/09]
- MRC-UK PET Methodology programme [G1100809/1]
- MRC [G0900891, G1100810, MC_U120036861] Funding Source: UKRI
- Medical Research Council [MC_U120036861, G1100810, G0900891] Funding Source: researchfish
The pathophysiological correlates and the contribution to persisting disability of hypointense T1-weighted MRI lesions, black holes (BH), in multiple sclerosis (MS) are still unclear. In order to study the in vivo functional correlates of this MRI finding, we used 11C-PK11195 PET (PK-PET) to investigate changes in microglial activity. Ten relapsing and 9 progressive MS subjects had a PK-PET scan and a MRI scan alongside a full clinical assessment, including the expanded disability status scale (EDSS) for evaluation of disability. We studied the PK binding potential of the specifically bound radioligand relative to the non-displaceable radioligand in tissue (BPND) in T1 BHs. Out of a total of 1242 BHs identified, 947 were PK enhancing. The PKBPND was correlated with the EDSS (r = 0.818; p < 0.05) only in the progressive group. In the relapsing patients there was an inverse correlation between PKBPND and BH total lesion volume in whole brain (r = -0.781; p < 0.05). When progressive patients were grouped according to the disability outcome at 2 years from the PK-PET scan, the total PKBPND in BHs was found to be a significant outcome predictor of disability (p < 0.01). Our findings show that relapsing and progressive patients have heterogeneous patterns of PKBPND in T1 BHs and indicate that BHs are not just holes representing loss of axons and myelin, but display inflammatory activity in the form of activated microglia. The significant association between PKBPND, neurological impairment and outcome in progressive subjects supports a role for activated microglia in disability progression. (C) 2014 Elsevier Inc. All rights reserved.
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