期刊
NEUROBIOLOGY OF DISEASE
卷 57, 期 -, 页码 38-46出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nbd.2012.06.025
关键词
Parkinson's disease; Gene-environment interaction; Pathogenesis
资金
- National Institutes of Health [4R00ES01 9879, 1P01NS059806, 1R01ES020718, 1RC1ES018058]
- Michael J. Fox Foundation
- JPB Foundation
Interactions between genetic factors and environmental exposures are thought to be major contributors to the etiology of Parkinson's disease. While such interactions are poorly defined and incompletely undetstood, recent epidemiological studies have identified specific interactions of potential importance to human PD. In this review, the most current data on gene-environment interactions in PD from human studies are critically discussed. Animal models have also highlighted the importance of genetic susceptibility to toxicant exposure and data of potential relevance to human PD are discussed. Goals and needs for the future of the field are proposed. (C) 2012 Elsevier Inc. All rights reserved.
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