期刊
NEUROBIOLOGY OF DISEASE
卷 45, 期 2, 页码 796-803出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nbd.2011.11.003
关键词
Endophenotypes; Kalirin; Schizophrenia; Schizoaffective; Auditory cortex; Dendrite
资金
- NIH [MH071533, MH084053, MH071316, F31AG031621-01A2, 1F31MH087043]
- Doris Duke Charitable Foundation
- BMS Foundation
- Bristol-Myers Squibb
- Curridium Ltd
- Pfizer
Reductions in dendritic arbor length and complexity are among the most consistently replicated changes in neuronal structure in post mortem studies of cerebral cortical samples from subjects with schizophrenia, however, the underlying molecular mechanisms have not been identified. This study is the first to identify an alteration in a regulatory protein which is known to promote both dendritic length and arborization in developing neurons, Kalirin-9. We found Kalirin-9 expression to be paradoxically increased in schizophrenia. We followed up this observation by overexpressing Kalirin-9 in mature primary neuronal cultures, causing reduced dendritic length and complexity. Kalirin-9 overexpression represents a potential mechanism for dendritic changes seen in schizophrenia. Published by Elsevier Inc.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据