期刊
NEUROBIOLOGY OF DISEASE
卷 42, 期 3, 页码 506-513出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nbd.2011.03.003
关键词
Oligodendrocyte; Astrocyte; Gap junctions; Connexins
资金
- NIH [NS55284]
- Boespflug Foundation
In addition to the extensive gap junction coupling between astrocytes themselves, oligodendrocytes are thought to be exclusively coupled to astrocytes (0:A coupling) via heterotypic gap junctions composed of Cx47:Cx43 and Cx32:Cx30. We used fluorescent dyes to examine functional coupling in acute slices from the cerebra of mice lacking Cx32 and/or Cx47. In the corpus callosum, unexpectedly, oligodendrocytes appeared to be directly and exclusively coupled to other oligodendrocytes (0:0 coupling), and electron microscopy revealed gap junctions between adjacent oligodendrocytes. 0:0 coupling was more affected in mice lacking Cx32 than in mice lacking Cx47. In the neocortex, oligodendrocytes appeared to be directly and exclusively coupled to astrocytes; Cx47, but not Cx32, was required for 0:A coupling. (C) 2011 Elsevier Inc. All rights reserved.
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