期刊
NEUROBIOLOGY OF DISEASE
卷 41, 期 2, 页码 249-260出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nbd.2010.09.012
关键词
Huntington disease; Adult neurogenesis; Cell proliferation; Dentate gyrus; Subventricular zone; YAC128 transgenic mice; Hippocampus
资金
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- Michael Smith Foundation for Health Research (MSFHR)
- Portuguese Foundation for Science and Technology (FCT) [SFRH/BPD/28799/2006]
- Canadian Institute of Health Research (CIHR)
- Huntington Society of Canada
- Huntington's Disease Society of America
- CHDI Foundation
- Fundação para a Ciência e a Tecnologia [SFRH/BPD/28799/2006] Funding Source: FCT
Perturbations in neurogenesis in the adult brain have been implicated in impaired learning and memory. In the present study, we investigated which stages of the neurogenic process are affected in the transgenic YAC128 mouse model of Huntington disease (HD). Hippocampal neuronal proliferation was altered in the dentate gyrus (DG) of YAC128 mice as compared with wild-type (WT) littermate controls in early symptomatic to end-stage mice. In addition, we detected a significantly lower number of immature neurons in the DG of young, pre-symptomatic YAC128 mice. This decrease in neuronal differentiation persisted through the progression of the disease, and resulted in an overall reduction in the number of new mature neurons in the DG of YAC128 mice. There were no changes in cell proliferation and differentiation in the subventricular zone (SVZ). In this study, we demonstrate decreases in neurogenesis in the DG of YAC128 mice, and these deficits may contribute to the cognitive abnormalities observed in these animals. Crown Copyright (C) 2010 Published by Elsevier Inc. All rights reserved.
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