期刊
NEUROBIOLOGY OF DISEASE
卷 41, 期 1, 页码 138-146出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nbd.2010.09.001
关键词
Cerebellum; Hypoxia; Ischemia; Neuronal death; Purkinje cells; Granule cells; White matter; Development
资金
- Journees Francophones de Recherche en Neonatologie (JFRN)
- Assistance Publique Hopitaux de Paris (APHP)
- National Institute of Health [NS35902]
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS044025, P50NS035902] Funding Source: NIH RePORTER
Two-day-old (P2) rat pups were subjected to either a global hypoxia or to electrocoagulation of the right carotid artery followed by 2.5 h hypoxia. Cellular and regional injury in the cerebellum (CB) was studied at 1, 2 and 19 days using immunohistology. Following hypoxia and hypoxia-ischemia, all neuronal populations of the CB were damaged in a subset of Purkinje cells. The decrease in the number of interneurons, as well as the thickness of molecular and granular layers was significant following hypoxia. Diffuse white matter damage, with loss of preoligodendrocytes was more severe following hypoxia than hypoxia-ischemia. Global hypoxia in the rat at P2 produces extensive damage to many cell types in different areas of the CB. The addition of unilateral forebrain ischemia does not increase the severity of these changes. Our data provide insight into the mechanisms of the changes observed in the CB of premature newborns. (C) 2010 Elsevier Inc. All rights reserved.
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