期刊
NEUROBIOLOGY OF DISEASE
卷 38, 期 2, 页码 266-272出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nbd.2010.01.016
关键词
Adhesive removal task; Behavior; Cerebral damage; Cognition; Cylinder rearing test; Hypoxia-ischemia; Rats; Modified hole board; Neonatal; NF-kappa B
We recently demonstrated that inhibition of the NF-kappa B-pathway by the specific peptide inhibitor TAT-NBD markedly reduced cerebral injury in a rat model of perinatal hypoxic-ischemic (HI) brain damage. The aim of the current study was to assess whether neuroprotection by TAT-NBD is associated with long-term functional improvements after neonatal HI. Postnatal-day 7 rats subjected to HI showed motor deficits in the cylinder rearing test and adhesive removal task. HI-treated animals also showed cognitive impairments in a visuo-spatial learning task (modified hole board) as defined by an increased latency to complete this task and increased numbers of short- and long-term memory errors. HI animals treated with TAT-NBD [20 mg/kg i.p.] at 0 and 3 h post-HI did not show impairments in the cylinder rearing test, adhesive removal task and modified hole board. In conclusion, the almost complete reduction in lesion size observed after TAT-NBD treatment was associated with long-lasting normalization of sensorimotor and cognitive functions. (C) 2010 Elsevier Inc. All rights reserved.
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