期刊
NEUROBIOLOGY OF DISEASE
卷 40, 期 1, 页码 66-72出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nbd.2010.05.016
关键词
Zebrafish; Addiction; Anxiety; Schizophrenia; Autism
资金
- National Institutes of Health
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS042626] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM [R01AA016021] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [R01DA023904] Funding Source: NIH RePORTER
Despite massive research efforts the exact pathogenesis and pathophysiology of addiction and neuropsychiatric disorders such as anxiety, schizophrenia and autism remain largely unknown. Animal models can serve as tools to understand the etiology and pathogenesis of these disorders. In recent years researchers are turning to zebrafish as it allows easy access to all developmental stages and imaging of pathological processes as well as automated behavioral quantification coupled with large scale screening and mutagenesis strategies. This review summarizes studies conducted over the last few years which demonstrate the relevance of the zebrafish model to human diseases including addiction and neuropsychiatric disorders. (C) 2010 Elsevier Inc. All rights reserved.
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