期刊
NEUROBIOLOGY OF DISEASE
卷 38, 期 2, 页码 288-298出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nbd.2010.01.020
关键词
Dystonia; Basal ganglia; Entopeduncular; Substantia nigra; Stimulation; Extracellular recordings
资金
- Centre National de la Recherche Scientifique
- Universite Victor Segalen Bordeaux 2
- Region Aquitaine
- IFR de Neurosciences
- Deutsche Forschungsgemeinschaft [RI845/1-3]
Dystonia is a heterogeneous syndrome of movement disorders characterized by involuntary muscle contractions leading to abnormal movements and postures. While medical treatment is often ineffective, deep brain stimulation (DBS) of the internal pallidum improves dystonia. Here, we studied the impact of DBS in the entopeduncular nucleus (EP), the rodent equivalent of the human globus pallidus internus, on basal ganglia output in the dt(sz)-hamster, a well-characterized model of dystonia by extracellular recordings. Previous work has shown that EP-DBS improves dystonic symptoms in dt(sz)-hamsters. We report that EP-DBS changes firing pattern in the EP, most neurons switching to a less regular firing pattern during DBS. In contrast, EP-DBS did not change the average firing rate of EP neurons. EP neurons display multiphasic responses to each stimulation impulse, likely underlying the disruption of their firing rhythm. Finally, neurons in the substantia nigra pars reticulata display similar responses to EP-DBS, supporting the idea that EP-DBS affects basal ganglia output activity through the activation of common afferent fibers. (C) 2010 Elsevier Inc. All rights reserved.
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