期刊
NEUROBIOLOGY OF DISEASE
卷 33, 期 3, 页码 429-435出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nbd.2008.11.011
关键词
Parkinson's disease; Oxidative stress; Peripheral blood; Disease severity
资金
- Chang Gung Memorial Hospital [CMRPG 37056, CMRPG330723]
- National Science Council of Taiwan [NSC 96-2314-B-182A-107-MY2, NSC95-2320-B-182020]
- Ministry of Education of Taiwan [EMRPD160241]
Increased oxidative stress contributes to neuronal dysfunction in Parkinson's disease (PD). We investigated whether the pathological changes in PD brains may also be present in peripheral tissues. Leukocyte 8-hydroxydeoxyguanosine (8-OHdG), plasma malondialdehyde (MDA), erythrocyte glutathione peroxidase (GPx) and plasma vitamin E (Vit E) were measured for 211 PD patients and 135 healthy controls. Leukocyte 8-OHdG and plasma MDA were elevated, whereas erythrocyte GPx and plasma Vit E were reduced in PD patients when compared to the controls. After adjusting for environmental factors, logistic regression analysis showed that PD severity was independently correlated with 8-OHdG and MDA level, and inversely correlated with GPx activity and Vit E level. Leucocyte 8-OHdG level was continuously increased with advanced PD Hoehn-Yahr stages, while plasma MDA level peaked at early disease stages, among PD patients. These results suggest increased oxidative damage and decreased anti-oxidant capacity in peripheral blood, and a significant correlation between leucocyte 8-OHdG level and disease severity in PD. (C) 2008 Elsevier Inc. All rights reserved.
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