期刊
NEUROBIOLOGY OF DISEASE
卷 35, 期 3, 页码 399-405出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nbd.2009.05.022
关键词
C-Fos; Cytochrome oxidase; Deep brain stimulation; Internal pallidum
资金
- Centre National de la Recherche Scientifique
- Universite Victor Segalen Bordeaux 2
- Region Aquitaine and IFR de Neurosciences
- Deutsche Forschungsgemeinschaft [R1845/1-3]
High frequency stimulation (HFS) of the internal pallidum is effective for the treatment of dystonia. Only few studies have investigated the effects of stimulation on the activity of the cortex-basal ganglia network. We here assess within this network the effect of entopeduncular nucleus (EP) HFS on the expression of c-Fos and cytochrome oxidase subunit I (COI) in the dt(sz)-hamster, a well-characterized model of paroxysmal dystonia. In dt(sz)-hamsters, we identified abnormal activity in motor cortex, basal ganglia and thalamus. These structures have already been linked to the pathophysiology of human dystonia. EP-HFS (i) increased striatal c-Fos expression in controls and dystonic hamsters and (ii) reduced thalamic c-Fos expression in dt(sz)-hamsters. EP-HFS had no effect on COI expression. The present results suggest that EP-HFS induces a new network activity state which may improve information processing and finally reduces the severity of dystonic attacks in dt(sz)-hamsters. (C) 2009 Elsevier Inc. All rights reserved.
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