期刊
NEUROBIOLOGY OF DISEASE
卷 35, 期 2, 页码 209-218出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nbd.2009.04.011
关键词
Gamma oscillations; High-frequency oscillations; Epilepsy; Kainic acid model; Hippocampus; Amygdala; Temporal lobe seizures; Ictogenesis; Local field potentials; In vivo recordings
资金
- Fondation de I'Hopital Ste-Justine
- Fondation de la recherche sur les maladies infantiles
- Canadian Institute for Health Research
- Scottish Rite Charitable Foundation of Canada
In this study, we demonstrate that gamma oscillations (30-50 Hz) recorded in the local field potentials (LFP) of the hippocampus are a marker of temporal lobe seizure propagation and that the level of LFP synchrony in the amygdalo-hippocampal network, during these oscillations, is related to the severity of seizures. Sprague-Dawley rats were given a single systemic dose of kainic acid (KA; 6 mg/kg, i.p.) and local field potential activity (1-475 Hz) of the dorsal hippocampus, the amygdala and the neocortex was recorded. Of 135 ictal discharges, 55 (40.7%) involved both limbic structures. We demonstrated that 78.2% of seizures involving both the hippocampus and amygdala showed hippocampal gamma oscillations. Seizure duration was also significantly correlated with the frequency of hippocampal gamma oscillations (r(2) = 0.31, p<0.01) and LFP synchrony in the amygdalo-hippocampal network (r(2)=0.21, p<0.05). These results suggest that gamma oscillations in the amygdalo-hippocampal network could facilitate long-range synchrony and participate in the propagation of seizures. (C) 2009 Elsevier Inc. All rights reserved.
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