期刊
NEUROBIOLOGY OF DISEASE
卷 31, 期 2, 页码 218-229出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nbd.2008.04.009
关键词
alcoholism; regeneration; ethanol; hippocampus; cortex; progenitor; stem cell; adult neurogenesis; microglia; neurodegeneration
资金
- NIAAA NIH HHS [R37 AA006069, R01 AA016959-02, P60 AA011605-11, R37 AA006069-18, R01 AA016959, P60 AA011605] Funding Source: Medline
Excessive alcohol intake characteristic of Alcohol Use Disorders (AUDs) produces neurodegeneration that may recover with abstinence. The mechanism of regeneration is unclear, however neurogenesis from neural stem/progenitor cells is a feasible mechanism of structural plasticity. Therefore, a timecourse of cell proliferation was examined in a rat model of an AUD and showed a striking burst in cell proliferation at 2 days of abstinence preceding the previously reported neurogenic proliferation at 7 days. New cells at 2 days, assessed by bromo-deoxy-uridine incorporation and endogenous markers, were observed throughout hippocampus and cortex. Although the majority of these new cells did not become neurons, neurogenesis was not altered at this specific time point. These new cells expressed a microglia-specific marker, Iba-1, and survived at least 2 months. This first report of microglia proliferation in a model of an AUD suggests that microgliosis could contribute to volume recovery in non-neurogenic regions during abstinence. (C) 2008 Elsevier Inc. All rights reserved.
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