期刊
NEUROBIOLOGY OF AGING
卷 73, 期 -, 页码 115-122出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2018.09.017
关键词
Short-term memory; Long-term memory; Alzheimer's disease; Apolipoprotein-E
资金
- Wellcome Trust [104571/Z/14/Z, 098282/Z/12/Z, 203130/Z/16/Z]
- British Academy
- National Institute for Health Research (NIHR) based at Oxford University Hospitals NHS Trust
- NIHR Oxford Health BRC
- Wellcome Trust [098282/Z/12/Z] Funding Source: Wellcome Trust
- MRC [MR/L023784/1, MC_EX_MR/N50192X/1, MR/M024962/1] Funding Source: UKRI
Short- and long-term memory performance as a function of apolipoprotein-E (APOE) genotype was examined in older, healthy individuals using sensitive and comparable tasks to provide a more detailed description of influences of the epsilon 4 allele (highest genetic risk factor for Alzheimer's disease) on memory. Older heterozygous and homozygous epsilon 4 carriers and noncarriers performed 2 tasks of memory. Both tasks allowed us to measure memory for item identity and locations, using a sensitive, continuous measure of report. Long-term memory for object locations was impaired in epsilon 4/epsilon 4 carriers, whereas, paradoxically, this group demonstrated superior short-term memory for locations. The dissociable effects of the gene on short- and long-term memory suggest that the effect of genotype on these two types of memories, and their neural underpinnings, might not be co-extensive. Whereas the long-term memory impairment might be linked to preclinical Alzheimer's disease, the short-term memory advantage may reflect an independent, phenotypical effect of this allele on cognition. (C) 2018 The Author(s). Published by Elsevier Inc.
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