期刊
NEUROBIOLOGY OF AGING
卷 71, 期 -, 页码 156-160出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2018.07.015
关键词
Working memory; Prefrontal cortex; Glucocorticoids; Corticosterone; Hypothalamic-pituitary-adrenal axis; Stress; Circadian; Normal aging
资金
- NIH [F32AG051371, R01AG029421]
- McKnight Brain Research Foundation
- NATIONAL INSTITUTE ON AGING [R01AG029421, F32AG051371] Funding Source: NIH RePORTER
A substantial literature details the relationship between age-related changes to the hypothalamic-pituitary-adrenal axis and deterioration of mnemonic functions that depend on the hippocampus. The relationship between adrenocortical status and other forms of memory that depend on the prefrontal cortex is less well understood in the context of advanced age. Here, we characterized performance of young adult and aged F344 rats on a prefrontal cortex-dependent working memory task and subsequently measured corticosterone (CORT) levels over the diurnal cycle and during exposure to an acute stressor. Our analyses revealed that aged rats with better working memory mounted a greater CORT response during acute stress exposure than either young adults or age-matched rats with impaired working memory. We also observed that age-related elevation of basal CORT levels is not associated with working memory performance. Jointly, these data reveal that the hypothalamic-pituitary-adrenal axis-mediated response to acute stress is positively associated with working memory in aging. (C) 2018 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据