期刊
NEUROBIOLOGY OF AGING
卷 35, 期 10, 页码 2230-2238出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2014.02.027
关键词
Sarcopenia; Spinal cord; Motor neuron; Mitochondria; mtDNA; Complex I
资金
- UK Medical Research Council [G0400074]
- Joint UK Medical Research Council/ Wellcome Trust Human Developmental Biology Resource [G0700089, GR082557]
- Newcastle University Centre for Brain Ageing and Vitality (Biotechnology and Biological Sciences Research Council, Engineering and Physical Sciences Research Council, Economic and Social Research Council and Medical Research Council) [G0700718]
- UK NIHR Biomedical Research Centre in Age and Age Related Diseases award
- Newcastle upon Tyne Hospitals NHS Foundation Trust
- MRC Centre for Neuromuscular Disease [G000608-1]
- Wellcome Trust Centre for Mitochondrial Research [096919/Z/11/Z]
- Lily Foundation
- UK NHS Specialist Commissioners Rare Mitochondrial Disorders of Adults and Children Service
- Multiple Sclerosis Society of Great Britain and Northern Ireland [207495]
- MRC [MR/K006312/1, G1100540, MC_PC_15004, G0700089, G0400074, G0502157, G0900652, G0700718] Funding Source: UKRI
- Medical Research Council [G0502157, G0400074, G0700089, MC_PC_15004, G0700718, MR/K006312/1, G1100540, G0900652] Funding Source: researchfish
- NIHR Newcastle Biomedical Research Centre [BH111030] Funding Source: researchfish
Sarcopenia, muscle wasting, and strength decline with age, is an important cause of loss of mobility in the elderly individuals. The underlying mechanisms are uncertain but likely to involve defects of motor nerve, neuromuscular junction, and muscle. Loss of motor neurons with age and subsequent denervation of skeletal muscle has been recognized as one of the contributing factors. This study investigated aspects of mitochondrial biology in spinal motor neurons from elderly subjects. We found that protein components of complex I of mitochondrial respiratory chain were reduced or absent in a proportion of aged motor neuronse-a phenomenon not observed in fetal tissue. Further investigation showed that complex I-deficient cells had reduced mitochondrial DNA content and smaller soma size. We propose that mitochondrial dysfunction in these motor neurons could lead to the cell loss and ultimately denervation of muscle fibers. (C) 2014 The Authors. Published by Elsevier Inc. All rights reserved.
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