4.5 Article

Forced exercise protects the aged optic nerve against intraocular pressure injury

期刊

NEUROBIOLOGY OF AGING
卷 35, 期 7, 页码 1722-1725

出版社

ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2014.01.019

关键词

Exercise; Optic nerve; Retina; Neuroprotection

资金

  1. Ophthalmic Research Institute of Australia/WA Quinlivan/Glaucoma Australia Grant
  2. Dorothy Adele Edols Charitable Trust
  3. National Health and Medical Research Council Centre for Clinical Research Excellence-Translational Clinical Research in Major Eye Diseases [529923]

向作者/读者索取更多资源

We have previously shown that the optic nerve of mice becomes increasingly vulnerable to injury with advancing age. Here, we investigated whether regular exercise can modify this age-related vulnerability and improve optic nerve recovery after injury. Aged (12-month-old) C57BL/6J mice were exercised by swimming for 60 min/d, 5 d/wk for 6 weeks. After 5 weeks, injury to the optic nerve was induced by short-term elevation of intraocular pressure. Retinal function was recorded using the electroretinogram and the cellular and biochemical changes induced by injury were assessed using immunohistochemistry and quantitative polymerase chain reaction. We found that exercise almost completely reversed age-related vulnerability of the optic nerve to injury such that exercised aged mice had a similar functional response to injury as non-exercised young (3-month-old) mice. Exercise also abrogated injury-induced astrocytic gliosis and macrophage activation in the aged retina. These data suggest that the known benefits of exercise also extend to the visual system and support further investigation of physical activity as a means of protecting against injury, dysfunction, and degeneration in the aging eye. (C) 2014 Elsevier Inc. All rights reserved.

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