期刊
NEUROBIOLOGY OF AGING
卷 35, 期 7, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2014.01.015
关键词
Mitochondrial DNA; Copy number; Aging; Longevity; Age-related diseases
资金
- National Basic Research Program of China [2013CB530802]
- Yunnan Province [2011FA024]
- Chinese Academy of Sciences
- Natural Science Foundation of China [31100909, 31123005, 31322029]
- Department of Science and Technology of Hainan Province [013GH XM0025]
Mitochondrial DNA (mtDNA) content plays an important role in energy production and sustaining normal physiological function. A decline in the mtDNA content and subsequent dysfunction cause various senile diseases, with decreasing mtDNA content observed in the elderly individuals with age-related diseases. In contrast, the oldest old individuals, for example, centenarians, have a delayed or reduced prevalence of these diseases, suggesting centenarians may have a different pattern of the mtDNA content, enabling them to keep normal mitochondrial functions to help delay or escape senile diseases. To test this hypothesis, a total of 961 subjects, consisting of 424 longevity subjects and 537 younger control subjects from Hainan and Sichuan provinces of China, were recruited for this study. The mtDNA content was found to be inversely associated with age among the age of group 40-70 years. Surprisingly, no reduction of mtDNA content was observed in nonagenarians and centenarians; instead, these oldest old showed a significant increase than the elderly people aged between 50 and 70 years. The results suggest the higher mtDNA content may convey a beneficial effect to the longevity of people through assuring sufficient energy supply. (C) 2014 Elsevier Inc. All rights reserved.
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