期刊
NEUROBIOLOGY OF AGING
卷 35, 期 1, 页码 122-129出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2013.06.024
关键词
Alzheimer's disease; Herpes virus latency; Quantitative real time PCR; Nested PCR; Peripheral blood samples; Brain tissue samples; Inflammatory plasma markers and cognitive decline
资金
- Italian Ministry for University and Research, Italy
- CARISBO Foundation Bologna, Italy
- BRACCO Pharmaceutics Milano, Italy
Studies regarding different viruses of the herpes family, such as cytomegalovirus (CMV), Epstein-Barr virus (EBV), or human herpes virus 6 (HHV-6) in Alzheimer's disease (AD) are scarce. DNA from peripheral blood leukocytes (PBL) and brain samples were analyzed for the presence of CMV, EBV, or HHV-6. All samples were negative for CMV. EBV positivity was 6% in AD brains, whereas 45% of PBL samples from AD patients and 31% from controls were positive for EBV (p = 0.05). HHV-6 showed a 23% positivity in PBL samples from AD and 4% from controls (p = 0.002). 17% of AD brains were HHV-6 positive. Within a group of elderly individuals, followed up for 5 years, EBV-positive or HHV-6-positive PBL increased in those who developed clinical AD. Virus serological positivity was also investigated, and IgG levels for CMV and EBV antigens were also increased in those subjects who developed AD during the follow-up. Our findings suggest that EBV and HHV-6 may be environmental risk factors for cognitive deterioration and progression to AD in elderly persons. (c) 2014 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据