期刊
NEUROBIOLOGY OF AGING
卷 34, 期 12, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2013.04.001
关键词
Mitochondrial DNA; Aging; Frailty; Genetics
资金
- Medical Research Council
- Biotechnology and Biological Sciences Research Council [G0500997, G0601333]
- Wellcome Trust [084980/Z/08/Z, 096919Z/11/Z]
- NIHR Newcastle Biomedical Research Centre based at Newcastle upon Tyne Hospitals NHS Foundation Trust
- Newcastle University
- Medical Research Council [MR/K000608/1, G0601333, G0500997] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0508-10260] Funding Source: researchfish
- Parkinson's UK [F-1202] Funding Source: researchfish
- Wellcome Trust [101876/B/13/Z] Funding Source: researchfish
- MRC [G0601333, MR/J50001X/1, G0500997, MR/K000608/1] Funding Source: UKRI
Inherited genetic variation of mitochondrial DNA (mtDNA) could account for the missing heritability of human longevity and healthy aging. Here, we show no robust association between common genetic variants of mtDNA and frailty (an unhealthy aging phenotype) or mortality in 700, more than 85-year-old, participants of the Newcastle 85+ study. Conflicting data from different populations underscore our conclusion that there is currently no compelling link between inherited mtDNA variants and aging. (C) 2013 The Authors. Published by Elsevier Inc. All rights reserved.
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