期刊
NEUROBIOLOGY OF AGING
卷 34, 期 4, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2012.08.011
关键词
FTLD; Schizophrenia; C9ORF72 repeat expansion; Psychosis
资金
- NIH/NIA [NIA P01AG07232, NIA R01AG037212]
- NIH/NINDS [R00 NS060766]
- Irving Institute of Columbia University
- National Institute of Mental Health (NIMH) [MH061399]
A hexanucleotide repeat expansion in C9ORF72 was recently found to cause some cases of frontotemporal lobar degeneration, frontotemporal dementia (FTD)-amyotrophic lateral sclerosis, and amyotrophic lateral sclerosis. Patients with frontotemporal lobar degeneration with the C9ORF72 repeat expansion are more likely than those without to present with psychosis. In this study, we screened DNA samples from 192 unrelated subjects with schizophrenia for the C9ORF72 repeat expansion. None of the subjects with schizophrenia had the pathogenic expansion. C9ORF72 repeat expansions either do not cause schizophrenia, or do so rarely (less than 1% of cases). (C) 2013 Elsevier Inc. All rights reserved.
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