期刊
NEUROBIOLOGY OF AGING
卷 34, 期 10, 页码 2287-2292出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2013.04.007
关键词
Noradrenergic system; Norepinephrine; Cognition; Aging
资金
- VA Puget Sound Mental Illness Research, Education and Clinical Center (MIRECC)
- VA Puget Sound Geriatric Research, Education, and Clinical Center
- VA Special Fellowship in Advanced Psychiatry (MIRECC)
- University of Washington's ADRC Pilot Study Award
- NIH/NIA [P50AG005136]
Adequate central nervous system noradrenergic activity enhances cognition, but excessive noradrenergic activity may have adverse effects on cognition. Previous studies have also demonstrated that noradrenergic activity is higher in older than younger adults. We aimed to determine relationships between cerebrospinal fluid (CSF) norepinephrine (NE) concentration and cognitive performance by using data from a CSF bank that includes samples from 258 cognitively normal participants aged 21-100 years. After adjusting for age, gender, education, and ethnicity, higher CSF NE levels (units of 100 pg/mL) are associated with poorer performance on tests of attention, processing speed, and executive function (Trail Making A: regression coefficient 1.5, standard error [SE] 0.77, p = 0.046; Trail Making B: regression coefficient 5.0, SE 2.2, p = 0.024; Stroop Word-Color Interference task: regression coefficient 6.1, SE 2.0, p = 0.003). Findings are consistent with the earlier literature relating excess noradrenergic activity with cognitive impairment. Published by Elsevier Inc.
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