期刊
NEUROBIOLOGY OF AGING
卷 34, 期 5, 页码 1380-1388出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2012.11.007
关键词
Alzheimer's disease (AD); CacyBP/SIP; S100A6; Amyloidosis; Tau mice; Phosphatase activity
资金
- WisTa Laboratory Ltd
- Ministry of Science and Higher Education of Poland [N N303 548439, N N303 312737]
- Nencki Institute of Experimental Biology
- Mazovia PhD fellowship
The calcyclin binding protein and Siah-1 interacting protein (CacyBP/SIP) protein was shown to play a role in the organization of microtubules. In this work we have examined the neuronal distribution and possible function of CacyBP/SIP in cytoskeletal pathophysiology. We have used brain tissue from Alzheimer's disease (AD) patients and from transgenic mice modeling 2 different pathologies characteristic for AD: amyloid and tau. In the brain from AD patients, CacyBP/SIP was found to be almost exclusively present in neuronal somata, and in control patients it was seen in the somata and neuronal processes. In mice doubly transgenic for amyloid precursor protein and presenilin 1 there was no difference in CacyBP/SIP neuronal localization in comparison with the nontransgenic animals. By contrast in tau transgenic mice, localization of CacyBP/SIP was similar to that observed for AD patients. To find the relation between CacyBP/SIP and tau we examined dephosphorylation of tau by CacyBP/SIP. We found that indeed it exhibited phosphatase activity toward tau. Altogether, our results suggest that CacyBP/SIP might play a role in AD pathology. (C) 2013 Elsevier Inc. All rights reserved.
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