期刊
NEUROBIOLOGY OF AGING
卷 33, 期 10, 页码 2521-2526出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2011.11.018
关键词
Functional connectivity; Diffusion tensor imaging; Aging; Motor control
资金
- National Institutes of Health [T32-AG00114-21]
- UM National Institutes of Health Claude D. Pepper Older Americans Independence Center [AG08808]
Numerous studies have identified age differences in brain structure and function that correlate with declines in motor performance. While these investigations have typically focused on activity in isolated regions of the brain, resting state functional connectivity magnetic resonance imaging (MRI) and diffusion tensor imaging allow for more integrative assessments of spatially disparate neural networks. The novel contribution of the current study is to combine both resting state functional connectivity and diffusion tensor imaging to examine motor corticocortical circuits in young and older adults. We find that relatively greater functional connectivity between the primary motor cortices was strongly associated with decreased structural connectivity and poorer motor performance solely in older adults. We suggest that greater functional connectivity in older adults may be reflective of a release from the normally predominantly inhibitory interhemispheric communication associated with the primary motor cortices. (C) 2012 Elsevier Inc. All rights reserved.
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