期刊
NEUROBIOLOGY OF AGING
卷 33, 期 5, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2011.10.023
关键词
Antioxidant diet; Reactive oxygen species; Age-related hearing loss; CBA/J mice; Hair cells; Spiral ganglion cells
资金
- NIA NIH HHS [P01 AG025164, P01 AG025164-05] Funding Source: Medline
Oxidative stress has been linked to noise-and drug-induced as well as age-related hearing loss. Antioxidants can attenuate the decline of cochlear structure and function after exposure to noise or drugs, but it is debated as to whether they can protect from age-related hearing loss. In a long-term longitudinal study, 10-month-old female CBA/J mice were placed on either a control or antioxidant-enriched diet and monitored through 24 months of age. Supplementation with vitamins A. C. and E, L-carnitine, and a-lipoic acid significantly increased the antioxidant capacity of inner ear tissues. However, by 24 months of age, the magnitude of hearing loss was equal between the two groups. Likewise, there were no significant differences in hair cell loss or degeneration of spiral ganglion cells. We conclude that dietary manipulations can alter cochlear antioxidant capacity but do not ameliorate age-related sensorineural hearing loss in the CBA/J mouse. (C) 2012 Elsevier Inc. All rights reserved.
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