期刊
NEUROBIOLOGY OF AGING
卷 33, 期 1, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2011.08.005
关键词
Genetics; Amyotrophic lateral sclerosis; Frontotemporal dementia; Finland
资金
- National Institute on Aging [Z01-AG000949-02]
- NIH [R01AG031278, R01AG038791]
- National Institute on Neurological Disorders and Stroke
- NIH/NIA [R01 AG26251]
- European Community [259867]
- Motor Neurone Disease Association of Great Britain
- ALS Association
- Angel Fund
- ALS Therapy Alliance
- Wellcome Trust
- Reta Lila Weston Foundation
- MRC
- Microsoft Research Foundation
- Helsinki University Central Hospital
- Finnish Academy
- Ministero della Salute
- Progetti Finalizzati
- Fondazione Vialli e Mauro for ALS
- Federazione Italiana Giuoco Calcio
- Hersenstichting Nederland
- NIHR specialist Biomedical Research Centre for Mental Health at the South London and Maudsley NHS Foundation Trust (SLaM)
- Institute of Psychiatry, King's College London
- NIHR
- NATIONAL INSTITUTE ON AGING [R01AG026251, R01AG038791, ZIAAG000934, ZIAAG000933, R01AG031278, Z01AG000949] Funding Source: NIH RePORTER
- MRC [MC_G1000735, G0700943, G0701441, G0701075] Funding Source: UKRI
- Alzheimers Research UK [ART-PG2010-1, ART-PPG2011A-14] Funding Source: researchfish
- Medical Research Council [G0701441, G0701075, G0801418B, MC_G1000735, G0700943] Funding Source: researchfish
We and others have recently reported an association between amyotrophic lateral sclerosis (ALS) and single nucleotide polymorphisms on chromosome 9p21 in several populations. Here we show that the associated haplotype is the same in all populations and that several families previously shown to have genetic linkage to this region also share this haplotype. The most parsimonious explanation of these data are that there is a single founder for this form of disease. (C) 2012 Elsevier Inc. All rights reserved.
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