期刊
NEUROBIOLOGY OF AGING
卷 33, 期 5, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2010.08.004
关键词
Insulin degrading enzyme; Alzheimer's disease; Genetics; Single nucleotide polymorphism; Association
资金
- National Key Technology R&D Program in the Eleventh Five-year Plan Period [2006BAI02B01]
- National Natural Science Foundation of China [30830045, 30600656]
- National Basic Research 973 Program [2006CB500700]
- Beijing Natural Science Foundation [7071004]
- New-Star plan of Science and Technology of Beijing [2004B12]
- Science and Technology Plan of Beijing Municipal Education Commission [KZ200910025005]
Alzheimer's disease (AD) has a complex pattern of inheritance and many genes have recently been reported to contribute to the disease susceptibility. We selected 106 SNPs within 16 candidate genes and performed a multistage association study using 4 sample sets consisting of 731 AD patients and 738 control subjects to identify genetic factors for AD in Han Chinese. A single nucleotide polymorphism (SNP) in the insulin degrading enzyme gene (IDE), rs3781239, showed a significant association with AD. The C allele increased the risk of AD 1.72-fold than the G allele (odds ratio [OR] = 1.72, 95% confidence interval [CI] = 1.17-2.53, p = 0.006) and CC carriers had a 4.89-fold higher risk for AD than that of the carriers with CG and GG genotypes (odds ratio = 4.89, 95% CI = 1.85-12.91, p = 0.001). Moreover, the CC genotype was significantly associated with earlier age at onset (p = 0.001, hazard ratio [HR] = 2.09, 95% CI = 1.38-3.18). Our data suggest that the polymorphism of IDE is associated with susceptibility to Alzheimer's disease in Han Chinese. (C) 2012 Elsevier Inc. All rights reserved.
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