期刊
NEUROBIOLOGY OF AGING
卷 33, 期 1, 页码 1-8出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2010.02.007
关键词
Aging; Alzheimer's Disease; Endophenotype; Genetics; Lateral ventricles; Mild cognitive impairment; Structural MRI; Twins
资金
- National Institute on Aging [AG022381, AG018384, AG018386, AG022982]
- National Center for Research Resources [P41-RR14075, BIRN002]
- National Institute for Biomedical Imaging and Bioengineering [R01EB006758]
- National Institute for Neurological Disorders and Stroke [R01 NS052585-01]
- Mental Illness and Neuroscience Discovery (MIND) Institute
- National Alliance for Medical Image Computing (nemic)
- National Institutes of Health through the NIH Roadmap for Medical Research [U54 EB005149]
- Autism and Dyslexia Project
- Ellison Medical Foundation
- US Department of Veterans Affairs
- NATIONAL CENTER FOR RESEARCH RESOURCES [P41RR014075, R01RR016594] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB006758, U54EB005149] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R21NS072652, R01NS052585] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG022982, R01AG022381, R01AG018386, R01AG018384] Funding Source: NIH RePORTER
Twin studies generally show great consistency for the heritability of brain structures. Ironically, the lateral ventricles-perhaps the most reliably measured brain regions of interest-are the most inconsistent when it comes to estimating genetic influences on their volume. Heritability estimates in twin studies have ranged from zero to almost 0.80. Here we aggregate heritability estimates from extant twin studies, and we review and reinterpret some of the findings. Based on our revised estimates, we conclude that lateral ventricular volume is indeed heritable. The weighted average heritability of the revised estimates was 0.54. Although accumulated environmental insults might seem most logical as the predominant cause of age-related ventricular expansion, the data strongly suggest that genetic influences on lateral ventricular volume are increasing with age. Genetic influences accounted for 32-35% of the variance in lateral ventricular volume in childhood, but about 75% of the variance in late middle and older age. These conclusions have implications for the basic understanding of the genetic and environmental underpinnings of normative and pathological brain aging. (C) 2012 Elsevier Inc. All rights reserved.
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