期刊
NEUROBIOLOGY OF AGING
卷 32, 期 8, 页码 1466-1476出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2009.08.017
关键词
Posterior cortical atrophy; Alzheimer's disease; Cortical thickness; Voxel-based morphometry; Magnetic resonance imaging
资金
- UK Department of Health's National Institute for Health Research Biomedical Research Centres
- Alzheimer's Society
- MRC (UK)
- Alzheimer's Research Trust (ART)
- Kirby Laing Foundation
- MRC [G0601846] Funding Source: UKRI
- Alzheimers Research UK [ART-RF2007-1] Funding Source: researchfish
- Alzheimer's Society [108] Funding Source: researchfish
- Medical Research Council [G0601846] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0508-10123] Funding Source: researchfish
A significant minority of Alzheimer's disease patients present with posterior cortical atrophy (PCA). PCA is characterized by visuospatial and visuoperceptual deficits, and relatively preserved memory, whereas patients with typical Alzheimer's disease (tAD) mostly present with early episodic memory deficits. We used two unbiased image analysis techniques to assess atrophy patterns in 48 PCA, 30 tAD, and 50 healthy controls. Free Surfer was used to measure cortical thickness, and volumetric grey matter differences were assessed using voxel-based morphometry (VBM). Both PCA and tAD showed widespread reductions compared with controls using both techniques. Direct comparison of PCA and tAD revealed thinner cortex predominantly in the right superior parietal lobe in the PCA group compared with tAD, whereas the tAD group showed thinning in the left entorhinal cortex compared with PCA. Similar results were obtained in the VBM analysis. These distinct patterns of atrophy may have diagnostic utility. In a clinical context, a relatively spared medial temporal lobe in the presence of posterior parietal atrophy may imply PCA, and should not discount AD. (C) 2009 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据