期刊
NEUROBIOLOGY OF AGING
卷 32, 期 7, 页码 1198-1206出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2009.07.008
关键词
MRI; Alzheimer's disease; Mild cognitive impairment; MCI
资金
- EU [LSHB-CT-2005-518170]
- Health Research Council of The Academy of Finland [121038]
- Kuopio University Hospital [5772720]
- Academy of Finland (AKA) [121038, 121038] Funding Source: Academy of Finland (AKA)
To study the ability of neuropsychological tests, manual MRI hippocampal volume measures, regional volume and cortical thickness measures to identify subjects with Alzheimer's disease (AD), mild cognitive impairment (MCI), and healthy age-matched controls. Neuropsychological tests, manual hippocampal volume, automated regional volume and regional cortical thickness measures were performed in 120 AD patients, 120 MCI subjects, and 111 controls. The regional cortical thickness and volumes in MCI subjects were significantly decreased in limbic/paralimbic areas and temporal lobe compared to controls. Atrophy was much more extensive in the AD patients compared to MCI subjects and controls. The combination of neuropsychological tests and volumes revealed the highest accuracy (82% AD vs. MCI; 94% AD vs. control; 83% MCI vs. control). Adding regional cortical thicknesses into the discriminate analysis did not improve accuracy. We conclude that regional cortical thickness and volume measures provide a panoramic view of brain atrophy in AD and MCI subjects. A combination of neuropsychological tests and regional volumes are important when discriminating AD from healthy controls and MCI. (C) 2009 Elsevier Inc. All rights reserved.
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