期刊
NEUROBIOLOGY OF AGING
卷 32, 期 4, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2010.12.011
关键词
Amyotrophic lateral sclerosis; Single nucleotide polymorphism; Genome-association study; Replication study; UNC13A; 9p21.2
资金
- Grants-in-Aid for Scientific Research [23500433] Funding Source: KAKEN
We performed a replication study of the 2 genetic variants, rs2814707 on 9p21.2 and rs12608932 on 19p13.3 that are recently reported to be most significantly associated with sporadic amyotrophic lateral sclerosis (ALS) in Caucasians. Both rs12608932 and rs2814707 showed no evidence of association in Japanese and Chinese (rs12608932, combined p = 0.58, odds ratio [OR] = 1.03, 95% confidence interval [CI] 0.93-1.13; rs2814707, combined p = 0.88, OR = 1.10, 95% CI 0.93-1.30). The association of these loci with susceptibility to sporadic ALS is considered negative in East Asians. (C) 2011 Elsevier Inc. All rights reserved.
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