期刊
NEUROBIOLOGY OF AGING
卷 32, 期 5, 页码 966-967出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2009.05.014
关键词
Amyotrophic lateral sclerosis; Genome-wide association study; Polymorphism; Dipeptidyl-peptidase 6 (DPP6) gene
资金
- Medical Research Council [G0500289, G0500289B, G0900688] Funding Source: researchfish
- MRC [G0500289, G0900688] Funding Source: UKRI
- Medical Research Council [G0900688, G0500289] Funding Source: Medline
- Wellcome Trust [089701] Funding Source: Medline
We have attempted to replicate a recently reported association of polymorphism rs10260404, in the Dipeptidyl-peptidase 6 gene (DPP6), with susceptibility to amyotrophic lateral sclerosis (ALS) in a large independent Italian cohort of 904 cases and 1036 controls. Minor allele frequency was 0.38 in cases and 0.39 in controls and no evidence of association with ALS was observed (P=0.638). Our negative results agree with those recently reported in additional Polish and Italian cohorts. (C) 2009 Elsevier Inc. All rights reserved.
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