4.5 Article

Association of early experience with neurodegeneration in aged primates

期刊

NEUROBIOLOGY OF AGING
卷 32, 期 1, 页码 151-156

出版社

ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2009.01.014

关键词

Aging; beta-Amyloid; Neurodegeneration; Environment; Neocortex; Rhesus monkey; Synapse density; Synaptophysin

资金

  1. NIH [AG10435]
  2. California Regional Primate Research Center [RR00169]
  3. Shiley Family Foundation
  4. NATIONAL CENTER FOR RESEARCH RESOURCES [P51RR000169] Funding Source: NIH RePORTER
  5. NATIONAL INSTITUTE ON AGING [P01AG010435] Funding Source: NIH RePORTER

向作者/读者索取更多资源

Environment influences brain development, neurogenesis and, possibly, vulnerability to neurodegenerative disease. We retrospectively examined the brains of aged rhesus monkeys reared during early life in either small cages or larger, standard-sized cages; all monkeys were subsequently maintained in standard-sized cages during adulthood. Aged monkeys reared in smaller cages exhibited significantly greater beta-amyloid plaque deposition in the neocortex and a significant reduction in synaptophysin immunolabeling in cortical regions compared to aged monkeys reared in standard-sized cages (p < 0.001 and p < 0.05, respectively). These findings suggest that early environment may influence brain structure and vulnerability to neurodegenerative changes in late life. Published by Elsevier Inc.

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