期刊
NEUROBIOLOGY OF AGING
卷 32, 期 11, 页码 1942-1948出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2009.12.005
关键词
Insulin resistance; Postmenopausal women; Alzheimer's disease; Hippocampal volume; APOE-epsilon 4; Dementia risk
资金
- National Institute on Aging [R01 AG22008]
- National Center for Research Resources [M01 RR-00070]
- National Institutes of Health
- [2 R01 AG022008-06A2]
Insulin resistance (IR) is the main pathological condition underlying vascular disorders, such as diabetes and cardiovascular disease, which are well established risk factors for cognitive decline and Alzheimer disease (AD). Hippocampal atrophy has been associated with cognitive decline, but little is known about the influence of IR on hippocampus integrity in non-diabetic, cognitively intact individuals. Herein, 50 women ages 50-65, current users of hormone therapy, underwent magnetic resonance imaging, cognitive testing, and homeostatic assessment of insulin resistance (HOMA-IR), as part of a longitudinal study examining brain structure and function in postmenopausal women at risk for AD. Results demonstrated a significant negative relationship between HOMA-IR and right and total hippocampal volume, overall cognitive performance, and selective tests of verbal and non-verbal memory. The main effect of HOMA-IR on brain structure and cognition was not altered by the presence of APOE-epsilon 4 allele or by reproductive history, such as duration of endogenous and exogenous estrogen exposure. These results suggest that IR in middle-aged individuals at risk for AD may be biomarker for dementia risk. (C) 2009 Elsevier Inc. All rights reserved.
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