期刊
NEUROBIOLOGY OF AGING
卷 31, 期 7, 页码 1173-1187出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2008.08.005
关键词
Alzheimer's disease; beta-Amyloidosis; Transgenic mice; Hippocampus; Memory; Synaptic transmission; Long-term potentiation (LTP); Transient long-term potentiation (t-LTP); Short-term potentiation (STP)
Alzheimer's disease (AD) is characterized by progressive memory impairment and the formation of amyloid plaques in the brain. Dysfunctional excitatory synaptic transmission and synaptic plasticity are generally accepted as primary events in the development of AD, and beta-amyloid is intimately involved. Here we describe age related differences in learning, memory, synaptic transmission and long-term potentiation (urp) in wild type and APPswe/PSI Delta E9 mice, which produce increasing amounts of A beta 1-42 with age. The mice have both age related and age-independent deficits in radial arm water maze performance. Blind studies of hippocampal slices from transgenic and wild type mice demonstrate that transgenic mice have impaired transient LTP and that the degree of impairment is not related to age from 3 to 12 months. The deficiencies in transient LTP may be related to the behavioral deficits that did not progress with age. The accumulation of p-amyloid and the episodic memory deficits, both of which increased with age, were not accompanied by an alteration in synaptic transmission or sustained LTP in the in vitro hippocampal slices. (C) 2008 Elsevier Inc. All rights reserved.
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