期刊
NEUROBIOLOGY OF AGING
卷 31, 期 2, 页码 244-256出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2008.03.013
关键词
Alzheimer; Aging; Diffusion tensor imaging; Fractional anisotropy; Diffusivity; MRI; White matter; Dementia; Hippocampus; Entorhinal; Memory; Axial diffusivity; Radial diffusivity; Tractography; Volume; Hyperintensities; T2; Myelin; Axon
资金
- NIH [K01 AG024898]
- Massachusetts Alzheimer's Disease Research Center Pilot [AG05886]
- National Center for Research Resources [P41RR14075]
- Mental Illness and Neuroscience Discovery (MIND) Institute
- National Alliance for Medical Image Computing (NAMIC) [U54 EB05149]
Prior work has demonstrated that the memory dysfunction of Alzheimer's disease (AD) is accompanied by marked cortical pathology in medial temporal lobe (MTL) gray matter. In contrast, changes in white matter (WM) of pathways associated with the MTL have rarely been studied. We used diffusion tensor imaging (DTI) to examine regional patterns of WM tissue changes in individuals with AD. Alterations of diffusion properties with AD were found in several regions including parahippocampal WM, and in regions with direct and secondary connections to the MTL. A portion of the changes measured, including effects in the parahippocampal WM, were independent of gray matter degeneration as measured by hippocampal volume. Examination of regional changes in unique diffusion parameters including anisotropy and axial and radial diffusivity demonstrated distinct zones of alterations, potentially stemming from differences in underlying pathology, with a potential myelin specific pathology in the parahippocampal WM. These results demonstrate that deterioration of neocortical connections to the hippocampal formation results in part from the degeneration of critical MTL and associated fiber pathways. (C) 2008 Elsevier Inc. All rights reserved.
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