期刊
NEUROBIOLOGY OF AGING
卷 30, 期 1, 页码 103-111出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2007.05.014
关键词
Tensor-based morphometry; Semantic dementia; Temporal lobe; Progression of gray matter atrophy; Longitudinal study
资金
- National Institute of Neurological Disorders and Stroke [R01 NS050915]
- State of California [DHS 04-35516]
- National Institute on Aging [P50 AG03006, P01 AG019724]
- John Douglas French Alzheimer's Foundation
- McBean Foundation
- Sandler Foundation
- Alzheimer's Disease Research Center of California [03-75271 DHS/ADP/ARCC]
- Larry Hill-blom Foundation [2002/2F]
- Koret Foundation [99-0102]
We performed a longitudinal anatomical study to map the progression of gray matter atrophy in anatomically defined predominantly left (LTLV) and right (RTLV) temporal lobe variants of semantic dementia (SD). TI-weighted MRI scans were obtained at presentation and one-year follow-up from 13 LTLV, 6 RTLV, and 25 control subjects. Tensor-based morphometry (TBM) in SPM2 was applied to derive a voxel-wise estimation of-regional tissue loss over time from the deformation held required to warp the follow-up scan to the presentation scan in each subject. When compared to controls, both LTLV and RTLV showed significant progression of gray matter atrophy not only within the temporal lobe most affected at presentation, but also in the controlateral temporal regions (p < 0.05 FWE corrected). In LTLV, significant progression of volume loss also involved the ventromedial frontal and the left anterior insular regions. These results identified the anatomic substartes of the previously reported clinical evolution of LTLV and RTLV into a unique 'merged' clinical syndrome characterized by semantic and behavioral deficits and bilateral temporal atrophy. (C) 2007 Elsevier Inc. All rights reserved.
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