期刊
NEUROBIOLOGY OF AGING
卷 30, 期 12, 页码 1902-1909出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2008.01.016
关键词
Alzheimer's disease; Dementia; Clinical Dementia Rating; Amyloid plaques; Positron emission tomography; Imaging; [18F]FDG; [11C]PIB; Pittsburgh Compound B
资金
- (Deutsche Forschungsgemeinschaft) [HE 4560/1-2]
Background: The positron emission tomography (PET) tracer [11C]-Pittsburgh Compound-B ([11C]PIB) allows the in vivo assessment of amyloid plaque burden in the brain. In a cross-sectional study we examined the association between the seventy of dementia assessed using the Clinical Dementia Rating scale sum of boxes (CDR-SOB) and [11C]PIB-PET in patients with Alzheimer's disease (AD). Methods: Patients with probable AD who had an AD-typical [18F]FDG-PET scan were included Linear regression analysis in anatomically defined regions-of-interest (ROIs) and correlation analysis using statistical parametric mapping (SPM) were used to determine the association between CDR-SOB and [11C]PIB uptake. Results: The linear regression analyses showed that the CDR-SOB explained approximately 11-22% of the variance of [11C]PIB uptake. The association attained statistical significance in both frontal, in both anterior cingulate cortices, and in both putamina. The SPM analysis showed a significant association in more widespread regions of the brain, with maxima located in similar areas as in the ROI-analysis. Conclusion: The CDR-SOB score is significantly associated with [11C]PIB uptake in patients with AD Thus [11C]PIB is a potential surrogate marker of dementia severity. (C) 2008 Elsevier Inc. All rights reserved.
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