期刊
NEUROBIOLOGY OF AGING
卷 29, 期 9, 页码 1296-1307出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2007.03.007
关键词
Alzheimer's disease; cognition; synapses; tangles
资金
- NIA NIH HHS [AG02219, AG05138, P50 AG005138-240023, P50 AG005138, P01 AG002219, P01 AG002219-280009] Funding Source: Medline
The loss of presynaptic markers is thought to represent a strong pathologic correlate of cognitive decline in Alzheimer's disease (AD). Spinophilin is a postsynaptic marker mainly located to the heads of dendritic spines. We assessed total numbers of spinophilin-immunoreactive puncta. in the CA I and CA3 fields of hippocampus and area 9 in 18 elderly individuals with various degrees of cognitive decline. The decrease in spinophilin-immunoreactivity was significantly related to both Braak neurofibrillary tangle (NFT) staging and clinical severity but not A beta deposition staging. The total number of spinophilin-immunoreactive puncta in CA I field and area 9 were significantly related to MMSE scores and predicted 23.5 and 61.9% of its variability. The relationship between total number of spinophilin-immunoreactive puncta in CA I field and MMSE scores did not persist when adjusting for Braak NFT staging. In contrast, the total number of spinophilin-immunoreactive puncta in area 9 was still significantly related to the cognitive outcome explaining an extra 9.6% of MMSE and 25.6% of the Clinical Dementia Rating scores variability. Our data suggest that neocortical dendritic spine loss is an independent parameter to consider in AD clinicopathologic correlations. (c) 2007 Elsevier Inc. All rights reserved.
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