期刊
NEURO-ONCOLOGY
卷 13, 期 1, 页码 3-13出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/neuonc/noq169
关键词
clinical trial; glioblastoma multiforme; immunotherapy; malignant gliomas
资金
- NIH [5RO1-CA135272-02, 3RO1-CA135272-02S1, 5P50-CA108786-05, 5P50-CA127001-03, 1R25-NS065731-01, 5P50-NS020023-27, 5R21-CA132891-02, 3R21CA 132891-02S1, R01-CA097222, R01-CA097611, P50CA108786, R01-CA1208113, R43 AI 77225-01]
- Golfers Against Cancer
- National Brain Tumor Foundation
- Neurosurgery Research and Education Foundation
- Shawn Hansen/American Brain Tumor Association
- Adam Sliger Research Fund
- Goodwin Fund for Clinical Trials
- National Brain Tumor Society
- Dr Marnie Rose Foundation
- Anthony Bullock III Foundation
- PBTFUS
- Brain Tumor Society
- Congress of Neurological Surgeons
- Southeastern Brain Tumor Foundation
- Accelerate Brain Cancer Cure/American Brain Tumor Association
- AANS/CNS
- Chandran Research Award
- NATIONAL CANCER INSTITUTE [R01CA097222, R21CA132891, R01CA135272, P50CA127001, P50CA108786, R01CA097611] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R43AI077225] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R25NS065731, P50NS020023] Funding Source: NIH RePORTER
With the recent approval by the FDA of an immunotherapy for prostate cancer and another positive immunotherapy trial in melanoma, immunotherapy may finally be coming of age. So what will it take for it to become part of the standard treatment for glioblastoma? To put this question into perspective, we summarize critical background information in neuro-immunology, address immunotherapy clinical trial design, and discuss a number of extrinsic factors that will impact the development of immunotherapy in neuro-oncology.
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