期刊
NEURO-ONCOLOGY
卷 12, 期 7, 页码 725-735出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/neuonc/noq030
关键词
database; glioblastoma; neuro-oncology; neurosurgery; survival
资金
- French Institut National du Cancer (INCa)
- Ligue Nationale Contre le Cancer
- Schering-Plough Laboratory
- Association des Neuro-Oncologues d'Expression Francaise
- Societe Francaise de Neurochirurgie
- Associations pour la Recherche sur les Tumeurs Cerebrales (ARTC and ARTC Sud)
- Department de l'Herault, Rotary Club (AGLY)
- Archimedes Pharma Laboratory
- Groupe de Neuro-Oncologie du Languedoc Roussillon
This report, an audit requested by the French government, describes oncological patterns of care, prognostic factors, and survival for patients with newly diagnosed and histologically confirmed glioblastoma multiforme (GBM) in France. The French Brain Tumor DataBase, which is a national multidisciplinary (neurosurgeons, neuropathologists, radiotherapists, neurooncologists, epidemiologists, and biostatisticians) network, prospectively collected initial data for the cases of GBM in 2004, and a specific data card was used to retrospectively collect data on the management and follow-up care of these patients between January 1, 2004, and December 1, 2006. We recorded 952 cases of GBM (male/female ratio 1.6, median age 63.9 years, mean preoperative Karnofsky performance status [KPS] 79). Surgery consisted of resection (RS; n = 541) and biopsy (n = 411); 180 patients did not have subsequent oncological treatment. After surgery, first-line treatment (n = 772) consisted of radiotherapy (RI) and temozolomide (TMZ) concomitant +/- adjuvant in 314 patients, RT alone in 236 patients, chemotherapy (CT) alone in 157 patients, and other treatment modalities in 65 patients. Median overall survival was 286 days (95% Cl, 266-314) and was significantly affected by age, KPS, and tumor location. Median survival (days, 95% Cl) associated with these main strategies, when analyzed by a surgical group, were as follows: RS + RT-TMZ((n=224)): 476 (441-506), biopsy + RT-TMZ((n=90)): 329 (301-413), RS + RT(n=147): 363 (331-431), biopsy + RT(n=89): 178 (153-237), RS + CT(n=61): 245 (190-361), biopsy + CT(n=96): 244 (198-280), and biopsy only((n=18)): 55 (46-71). This study illustrates the usefulness of a national brain tumor database. To our knowledge, this work is the largest report of recent GBM management in Europe.
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