期刊
NEURO-ONCOLOGY
卷 12, 期 1, 页码 7-13出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/neuonc/nop009
关键词
GBM; immune escape NKG2D; NK cell; TGF-beta
资金
- NIH [AI066897]
- Brain Tumor SPORE Grant [2 P50 CA097257-06]
- NATIONAL CANCER INSTITUTE [P50CA097257] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R37AI066897] Funding Source: NIH RePORTER
The activating receptor NKG2D, expressed by natural killer (NK) cells and CD8(+) T cells, has a role in the specific killing of transformed cells. We examined NKG2D expression In patients with glioblastoma multiforme and found that NKG2D was downregulated on NK cells and CD8(+) T cells. Expression of NKG2D on lymphocytes significantly increased following tumor resection and correlated with all increased ability to kill NKG2D ligand-positive tumor targets. Despite the presence of soluble NKG2D ligands in the sera of glioblastoma patients, NKG2D downregulation was primarily caused by tumor-derived tumor growth factor-beta, suggesting that blocking of this cytokine may have therapeutic benefit.
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