期刊
NEURAL REGENERATION RESEARCH
卷 9, 期 9, 页码 919-923出版社
MEDKNOW PUBLICATIONS & MEDIA PVT LTD
DOI: 10.4103/1673-5374.133133
关键词
nerve regeneration; bone marrow mesenchymal stem cells; traumatic brain injury; intravenous administration; cell differentiation; neurologic function, cerebral cortex; rats; neural regeneration
资金
- Shahid Sadoughi University of Medical Sciences, Yazd, Iran
To investigate the supplement of lost nerve cells in rats with traumatic brain injury by intravenous administration of allogenic bone marrow mesenchymal stem cells, this study established a Wistar rat model of traumatic brain injury by weight drop impact acceleration method and administered 3 x 106 rat bone marrow mesenchymal stem cells via the lateral tail vein. At 14 days after cell transplantation, bone marrow mesenchymal stem cells differentiated into neurons and astrocytes in injured rat cerebral cortex and rat neurological function was improved significantly. These findings suggest that intravenously administered bone marrow mesenchymal stem cells can promote nerve cell regeneration in injured cerebral cortex, which supplement the lost nerve cells.
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