期刊
NEURAL REGENERATION RESEARCH
卷 9, 期 17, 页码 1610-1615出版社
WOLTERS KLUWER MEDKNOW PUBLICATIONS
DOI: 10.4103/1673-5374.141787
关键词
nerve regeneration; chronic alcoholism; hydrogen sulfide; cystathionine-beta-synthase; learning; memory; F-actin; mitochondria; hippocampus; NSFC grant; neural regeneration
资金
- National Natural Science Foundation of China [81471351]
- Key Project of the Science and Technology Foundation of Henan Provincial Education Department of China [12A320013]
- Funds of Henan Province Health Technology Talents Innovative Project [3052]
- Open Fund of Henan Provincial Mental Hospital, Henan Key Laboratory of Biological Psychiatry
Chronic alcoholism can damage the cytoskeleton and aggravate neurological deficits. However, the effect of chronic alcoholism on hippocampal neurons remains unclear. In this study, a model of chronic alcoholism was established in rats that were fed with 6% alcohol for 42 days. Endogenous hydrogen sulfide content and cystathionine-beta-synthase activity in the hippocampus of rats with chronic alcoholism were significantly increased, while F-actin expression was decreased. Hippocampal neurons in rats with chronic alcoholism appeared to have a fuzzy nuclear membrane, mitochondrial edema, and ruptured mitochondrial crista. These findings suggest that chronic alcoholism can cause learning and memory decline in rats, which may be associated with the hydrogen sulfide/cystathionine-beta-synthase system, mitochondrial damage and reduced expression of F-actin.
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