期刊
NEURAL REGENERATION RESEARCH
卷 9, 期 9, 页码 968-972出版社
MEDKNOW PUBLICATIONS & MEDIA PVT LTD
DOI: 10.4103/1673-5374.133148
关键词
nerve regeneration; brain injury; acupuncture and moxibustion; pretreatment; Alzheimer's disease; axin; beta-catenin; NSFC grant; neural regeneration
资金
- National Natural Science Foundation of China [30772837]
- Wuhan Municipal Morning Sun Science and Technology Plan [200850731347]
To examine the possible correlation of aberrant Wnt signaling and pathological changes in Alzheimer's disease, we established a rat model of Alzheimer's disease and measured axin and beta-catenin expression in the hippocampus. Rats were pretreated with moxibustion or electroacupuncture, or both, at Baihui (GV20) and Shenshu (BL23). Axin expression was lower, beta-catenin expression was greater, and neuronal cytoplasmic edema was visibly prevented in the rats that had received the pretreatments. Our results suggest that the mechanism underlying the neuroprotective effect of acupuncture and moxibustion in Alzheimer's disease is associated with axin and beta-catenin expression in the Wnt signal transduction pathway.
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