期刊
NEURAL NETWORKS
卷 47, 期 -, 页码 81-87出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neunet.2013.03.013
关键词
Cerebellum; Purkinje cells; Learning; Conditioning; Timing; Temporal
资金
- Swedish Research Council [349-2007-8695, 09899]
- Soderberg foundation
- Krapperup foundation
According to a widely held assumption, the main mechanism underlying motor learning in the cerebellum, such as eyeblink conditioning, is long-term depression (LTD) of parallel fibre to Purkinje cell synapses. Here we review some recent physiological evidence from Purkinje cell recordings during conditioning with implications for models of conditioning. We argue that these data pose four major challenges to the LTD hypothesis of conditioning. (i) LTD cannot account for the pause in Purkinje cell firing that is believed to drive the conditioned blink. (ii) The temporal conditions conducive to LTD do not match those for eyeblink conditioning. (iii) LTD cannot readily account for the adaptive timing of the conditioned response. (iv) The data suggest that parallel fibre to Purkinje cell synapses are not depressed after learning a Purkinje cell CR. Models based on metabotropic glutamate receptors are also discussed and found to be incompatible with the recording data. (C) 2013 Elsevier Ltd. All rights reserved.
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