期刊
NEURAL NETWORKS
卷 22, 期 8, 页码 1113-1119出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neunet.2009.07.024
关键词
Gamma oscillation; GABA; Inhibition; Interneuron; Hippocampus
资金
- Wellcome Trust
- Hungarian Scientific Research Fund [T049517]
- Biotechnology and Biological Sciences Research Council, U.K
Neural networks of the brain display multiple patterns of oscillatory activity. Some of these rhythms are generated intrinsically within the local network, and can therefore be studied in isolated preparations. Here we discuss local-circuit mechanisms involved in hippocampal CA3 gamma oscillations, one of the best understood locally generated network patterns in the mammalian brain. Perisomatic inhibitory cells are crucial players in gamma oscillogenesis. They provide prominent rhythmic inhibition to CA3 pyramidal cells and are themselves synchronized primarily by excitatory synaptic inputs derived from the local collaterals of CA3 pyramidal cells. The recruitment of this recurrent excitatory-inhibitory feedback loop during hippocampal gamma oscillations suggests that local gamma oscillations not only control when, but also how many and which pyramidal cells will fire during each gamma cycle. (C) 2009 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据