期刊
NEPHRON EXPERIMENTAL NEPHROLOGY
卷 126, 期 4, 页码 167-174出版社
KARGER
DOI: 10.1159/000363323
关键词
Acute kidney injury; Ischemia-reperfusion injury; Heat-shock protein
资金
- Maurice Wohl Research Fellowship from the Royal College of Surgeons Edinburgh
- Mason Medical Research Trust Fellowship
- Medical Research Council Clinical Research Training Fellowship
- MRC [MR/L001233/1] Funding Source: UKRI
- Medical Research Council [MR/L001233/1] Funding Source: researchfish
The incidence of acute kidney injury due to ischaemia-reperfusion injury (IRI) is rising but effective treatments and preventative approaches are currently lacking. IRI is also an inevitable consequence of kidney transplantation and significantly contributes to delayed graft function. Heat-shock proteins (Hsps) are highly conserved and ubiquitously expressed molecular chaperones that help maintain and restore normal cellular function in the kidney following IRI. Hsp70 is one of the most frequently studied Hsps because of potential cytoprotective properties and attractiveness as a therapeutic target. However, the protective properties of Hsp70 in renal IRI are not fully understood and putative modes of protection include correction of protein conformation, cytoskeletal stabilisation, anti-inflammatory effects, requirement in autophagy, anti-apoptotic properties, influence over macrophage phenotype and stimulation of regulatory T cells. Significant clinical interest has been generated about the possibility of applying pharmacological agents to induce Hsp70 and prevent renal IRI, but prior to this, an increased mechanistic understanding of the protective nature of Hsp70 is needed. In particular, further investigation of Hsp expression on inflammatory cell behaviour is required as this could lead to the development of new therapeutic strategies for enhancing recovery following renal IRI and broaden the range of these therapies to a wider group of patients. (C) 2014 S. Karger AG, Basel
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